The use of cyclosporine, as well as other immunosuppressive agents, predisposes to the development of a variety of bacterial, fungal, parasitic and viral infections, often with opportunistic pathogens. Testosterone cypionate for sale the potential risk of these infections for the patient’s life, should maintain an effective system of preventive and curative measures, especially in cases of long-term use of combined immunosuppressive treatment.
During the first few weeks of therapy, Sandimmun may receive frequent and potentially dangerous complication of increased creatinine and urea in serum. These functional changes are reversible and dose-dependent, normalized at lower doses. With long-term treatment, some patients may develop structural changes in the kidney (eg interstitial fibrosis) which patients with kidney transplants should be differentiated from changes in chronic rejection. Sandimmun may also cause dose-dependent reversible increases in serum bilirubin and, rarely, liver enzymes. In these cases it is necessary to closely monitor the performance of the kidneys and liver. In the case of deviations from the norm these indicators may require dose reduction.
Elderly patients should be particularly careful to carry out monitoring of renal function.
When using Sandimmun in patients after transplantation should be carried out determining the concentration of cyclosporine in the blood.
In the treatment of Sandimmun shows regular monitoring of blood pressure; with an increase in blood pressure should appoint adequate antihypertensive therapy. Preference testosterone cypionate for sale should be given such antihypertensive drugs, which do not affect the pharmacokinetics of cyclosporine.
Since Sandimmun in rare cases cause minor reversible hyperlipidemia, it is recommended to determine the concentration of lipids in the blood before treatment and one month after initiation of therapy. With increasing concentrations of lipids should consider limiting fat intake from food and, if necessary, to reduce the dose of Sandimmun.
Cyclosporin increases the risk of hyperkalemia, especially in patients with impaired renal function. It should also be careful at simultaneous application of cyclosporine with potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists and potassium-containing drugs, as well as in cases of the use of diet, rich in potassium. In these cases it is recommended to control blood potassium concentration. Cyclosporin increases the excretion of magnesium organism that may lead to a clinically significant hypomagnesemia, especially peritransplantatsionnom period. In this connection, it is recommended to control peritransplantatsionnom period magnesium concentration in the blood, especially in the appearance of neurological symptoms. If necessary, magnesium prescribed drugs.
It is recommended to control the concentration of uric acid in blood serum, especially in patients with hyperuricemia preceding.
cases of anaphylactoid reactions (flushing and upper torso, bronchospasm with dyspnea and stridor, fluctuations in blood pressure and tachycardia) have been described in the polyoxyethylated castor oil, which is part of Sandimmun concentrate for / in the introduction. In this regard, particular care should be observed in patients who had previously to / introduced into the formulations containing polyethoxylated castor oil (e.g., formulations containing Cremophor IL), as well as for patients susceptible to allergic reactions. Patients receiving treatment for a concentrate Sandimmun / introduction should be kept under continuous observation for at least the first 30 minutes after the start of infusion and at frequent intervals thereafter. At the first signs of anaphylactoid reactions administration of the drug should be discontinued immediately.
In the room for infusion should be prepared in advance an aqueous solution of adrenaline (1: 1000) and equipment for oxygen therapy.
For the prevention of anaphylactoid reactions testosterone cypionate for sale can be used administering antihistamines (histamine H 1 receptors) before / in infusion Sandimmun.
Effects on ability to drive vehicles and use machines
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There is currently no data on the effect of Sandimmun on the ability to drive vehicles and use machines. anabolic steroids online shop
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