Santotitralgin analgesic, antipyretic, anti-inflammatory, antispasmodic, sedative effect. A combined preparation, which combines the properties of the active ingredients. Has a pronounced anti-inflammatory, antipyretic activity, analgesic activity, which testosterone cypionate reviews increases codeine (blocks the opiate receptors, stimulates the antinociceptive system and changes the emotional perception of pain). Phenobarbital has a sedative effect. Caffeine causes dilation of blood vessels in skeletal muscle, brain, heart, kidney; enhances mental and physical performance, helps to eliminate fatigue and drowsiness; raises blood pressure hypotension; gistogematicheskih increases the permeability barriers and enhances the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.
The components of the preparation are well absorbed in the gastrointestinal tract. Metamizole : in the intestinal wall is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in its turn is metabolized formyl-4-amino-antipyrine and other metabolites. The level of the active metabolite binding proteins is 50-60%. The excretion of metabolites passes through the kidneys. Furthermore, they are excreted in breast milk. Caffeine : well absorbed in the intestine, the half – 5 hours (inogda- to 10 hours). Write mainly kidneys as metabolites, about 10% – unchanged. Codeine : slightly bound to plasma proteins. Biotransformation in the liver (10% by demethylation proceeds to morphine). Excreted kidneys (5-15% – unchanged). Phenobarbital : bioavailability is 80%. The plasma protein binds to 50%, cross the placenta well. Biotransformed in the liver. The main metabolite does not possess pharmacological activity. Report the news, including 20-25% unchanged.
Indications for use . Take the case of weak and testosterone cypionate reviews moderately expressed pain syndrome of different genesis. It is especially effective for pain in the joints, muscles, sciatica, menstrual pain, neuralgia, as well as headache, migraine, toothache. It can be used for fevers, colds and other diseases involving pain and inflammation phenomena.
Contraindications . Hypersensitivity to the drug. Expressions of hepatic or renal function. Gastric ulcer and duodenal ulcer in the acute stage. Bronchospasm. Bronchial asthma.State, accompanied by respiratory depression. Increased intracranial pressure, head injury. Acute myocardial infarction. Irregular heartbeat. High blood pressure. Drunkenness. Glaucoma. Pregnancy and lactation. Children’s age – 12 years, deficiency of glucose-6-phosphate dehydrogenase; anemia, leukopenia. Pregnancy and lactation : The drug is contraindicated in pregnancy. If necessary, use during lactation testosterone cypionate results is necessary to resolve the issue of termination of breastfeeding. The caution used in patients with impaired hepatic or renal function, with gastric ulcer and duodenal ulcer in remission, the elderly, long-term alcohol history.
Dosage and administration . The drug is usually taken 1 tablet 1-3 times a day. The maximum daily dose -. 4 tablets drug should not be used longer than 5 days as an analgesic without a prescription .
Side effect . There are dyspeptic disorders testosterone cypionate reviews (nausea, vomiting, constipation), allergic skin reactions (rash, pruritus, urticaria), epigastric pain, dizziness, drowsiness, decreased psychomotor speed reactions, palpitations.Rarely – oppression blood, in high doses may impair liver function and kidney. Prolonged uncontrolled reception in high doses – addictive (weakening of the analgesic effect).
Overdosing Symptoms : nausea, vomiting, stomach pain, tachycardia, cardiac arrhythmias, weakness, drowsiness, light-headedness, respiratory depression. Treatment : induction vomiting, stomach wash, the appointment of adsorbents (activated charcoal), symptomatic therapy aimed at maintaining vital functions.
Interaction with other drugs . The simultaneous use of the drug with other non-narcotic analgesics may lead to increased toxicity. Tricyclic antidepressants, contraceptives oral, allopurinol increase the toxicity of sodium metamizol (dipyrone), which is part of the preparation. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken action Metamizole (dipyrone). Concomitant use of sodium metamizol (dipyrone) with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the analgesic effect of the drug.
Special instructions . Can interfere with building work that requires a high rate of mental and physical reactions (driving vehicles, operating machinery, appliances, etc.). The patient should be made aware of the fact that long-term use of the drug without proper medical supervision may develop addiction and formation drug dependence. The period of treatment should refrain from drinking alcohol. Using the drug for more than 5 days is necessary to monitor patterns of peripheral blood and functional state of the liver.
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